{"id":36,"date":"2015-10-21T11:13:23","date_gmt":"2015-10-21T10:13:23","guid":{"rendered":"http:\/\/blog.u-bourgogne.fr\/list-maps\/?page_id=36"},"modified":"2016-06-02T13:53:38","modified_gmt":"2016-06-02T12:53:38","slug":"university-college-cork","status":"publish","type":"page","link":"https:\/\/blog.ube.fr\/list-maps\/consortium\/beneficiaries\/university-college-cork\/","title":{"rendered":"University College Cork"},"content":{"rendered":"

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SCHOOL OF MICROBIOLOGY<\/strong><\/p>\n

Our research is focused upon two overlapping areas of interest; (1) the gastrointestinal phase of Listeria monocytogenes<\/em> infection and (2) microbe-host interactions in the gut via bile acid signaling. There has recently been a revolution in our understanding of how the gut microbiota influences the health of the host and in particular provides a barrier to infection. We are interested in understanding how Listeria monocytogenes<\/em> adapts to conditions encountered in the gut (elevated bile acids, elevated osmolarity and competition for nutrients) in order to survive and infect the host.
\nMy main collaborators in these areas are Prof. Colin Hill (School of Microbiology & APC Microbiome Institute) and Dr. Susan Joyce (School of Biochemistry and Cell Biology & APC Microbiome Institute). Much of our work is carried out within the APC Microbiome Institute (http:\/\/apc.ucc.ie<\/a> ) a Science Foundation Ireland (SFI) funded centre of excellence that works closely with industry to investigate the role of the microbiota in health and disease. The APC Microbiome Institute provides significant support for our work programme through platforms of technical expertise and facilities that underpin work in bioinformatics, tissue culture and preclinical models.
\nRecent work in our lab has led to an understanding of how bacterial bile acid metabolism influences host physiological processes (Joyce et al., 2014, PNAS; Joyce et al., 2014, Gut Microbes). Work in the area of Listeria<\/em> pathogenesis has highlighted gene systems that are necessary for foodborne infection (Cummins et al., 2013, Plos One; Gahan & Hill, 2014, Front Cell Infect Microbiol) and bile tolerance (Dowd et al., 2011, Infection & Immunity).<\/p>\n

Website of the School of Microbiology :<\/strong> http:\/\/www.ucc.ie\/en\/microbiology\/<\/a><\/p>\n

Website of the University:<\/strong> http:\/\/www.ucc.ie\/en\/<\/a><\/p>\n

ROLE IN THE PROJECT<\/strong><\/p>\n

Sub-project 2: Stress pre-adaptation and virulence potential of L.monocytogenes<\/em> in the food matrix<\/a><\/p>\n

STAFF INVOLVED<\/strong><\/p>\n

Cormac GAHAN
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Education<\/strong><\/p>\n