{"id":28,"date":"2015-10-21T11:11:17","date_gmt":"2015-10-21T10:11:17","guid":{"rendered":"http:\/\/blog.u-bourgogne.fr\/list-maps\/?page_id=28"},"modified":"2016-06-13T10:29:17","modified_gmt":"2016-06-13T09:29:17","slug":"recherche","status":"publish","type":"page","link":"https:\/\/blog.ube.fr\/list-maps-fr\/le-projet\/recherche\/","title":{"rendered":"Recherche"},"content":{"rendered":"<p class=\"titre2\" style=\"text-align: center;font-family: arial;color: #000000;font-size: 18px\"><strong style=\"color: #483d8b\">\u00a0LE PROGRAMME SCIENTIFIQUE DE LIST_MAPS<br \/>\n<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-family: calibri;color: #000000;padding-left: 60px;padding-right: 60px;font-size: 16px;text-align: justify\">Les m\u00e9canismes permettant \u00e0 <em style=\"color: #000000\">Listeria monocytogenes<\/em> de transiter et de persister dans des habitats tr\u00e8s vari\u00e9s restent encore mal connus. Il est cependant clair que la capacit\u00e9 d\u2019int\u00e9grer des signaux environnementaux et de d\u00e9velopper une r\u00e9ponse appropri\u00e9e aux conditions de son environnement participe au risque sanitaire associ\u00e9 \u00e0 la pr\u00e9sence de cette bact\u00e9rie dans les environnements alimentaires.<\/p>\n<p><a href=\"http:\/\/blog.ube.fr\/list-maps\/wp-content\/uploads\/sites\/34\/2015\/10\/contamination-cycle.png\" rel=\"attachment wp-att-1092\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1092 size-full\" src=\"http:\/\/blog.ube.fr\/list-maps\/wp-content\/uploads\/sites\/34\/2015\/10\/contamination-cycle.png\" alt=\"L.monocytogenes\" width=\"354\" height=\"252\" srcset=\"https:\/\/blog.ube.fr\/list-maps-fr\/wp-content\/uploads\/sites\/56\/2015\/10\/contamination-cycle.png 354w, https:\/\/blog.ube.fr\/list-maps-fr\/wp-content\/uploads\/sites\/56\/2015\/10\/contamination-cycle-300x214.png 300w, https:\/\/blog.ube.fr\/list-maps-fr\/wp-content\/uploads\/sites\/56\/2015\/10\/contamination-cycle-211x150.png 211w\" sizes=\"auto, (max-width: 354px) 100vw, 354px\" \/><\/a><\/p>\n<p style=\"font-family: calibri;color: #000000;padding-left: 60px;padding-right: 60px;font-size: 16px;text-align: justify\">Le c\u0153ur du projet scientifique de List_MAPS est d\u2019int\u00e9grer la r\u00e9ponse de la bact\u00e9rie aux conditions environnementales par une approche de biologie des syst\u00e8mes et comprendre comment les conditions environnementales peuvent influencer sa capacit\u00e9 \u00e0 g\u00e9n\u00e9rer une infection apr\u00e8s ingestion.<\/p>\n<p class=\"titre2\" style=\"font-family: calibri;font-size: 16px;text-align: justify;color: #000000;padding-left: 60px;padding-right: 60px\"><strong style=\"color: #483d8b\">Quatre dispositifs exp\u00e9rimentaux sont utilis\u00e9s pour \u00e9tudier en d\u00e9tail l\u2019\u00e9cologie de <em style=\"color: #483d8b\">Listeria monocytogenes<\/em> :<\/strong><\/p>\n<ol class=\"titre2\" style=\"font-family: calibri;text-align: justify;color: #000000;padding-left: 90px;padding-right: 90px;font-size: 16px;line-height: 30px\">\n<li style=\"color: #000000;line-height: 30px;font-size: 16px\">Le sol et la rhizosph\u00e8re (zone entourant les racines des plantes)<\/li>\n<li style=\"color: #000000;line-height: 30px;font-size: 16px\">Les biofilms de l\u2019environnement agro-alimentaire<\/li>\n<li style=\"color: #000000;line-height: 30px;font-size: 16px\">L\u2019aliment et les stress technologiques<\/li>\n<li style=\"color: #000000;line-height: 30px;font-size: 16px\">La souris comme mod\u00e8le d\u2019h\u00f4te pour l\u2019\u00e9tude du pouvoir infectieux<\/li>\n<\/ol>\n<p class=\"titre2\" style=\"font-family: calibri;font-size: 16px;text-align: justify;color: #483d8b;padding-left: 60px;padding-right: 60px\"><strong style=\"color: #483d8b\">Le r\u00e9seau \u00e9tudie notamment :<\/strong><\/p>\n<ul class=\"titre2\" style=\"font-family: calibri;text-align: justify;color: #000000;padding-left: 90px;padding-right: 90px;font-size: 16px;line-height: 30px\">\n<li style=\"color: #000000;line-height: 30px;font-size: 16px\">Les transcriptomes et prot\u00e9omes dans ces environnements complexes<\/li>\n<li style=\"color: #000000;line-height: 30px;font-size: 16px\">Les m\u00e9canismes d\u2019adaptation physiologique par des approches de g\u00e9n\u00e9tique inverse<\/li>\n<li style=\"color: #000000;line-height: 30px;font-size: 16px\">Les interconnections entre la r\u00e9ponse au stress, la communication cellulaire et le RNome<\/li>\n<li style=\"color: #000000;line-height: 30px;font-size: 16px\">La r\u00e9ponse \u00e0 l\u2019environnement biotique<\/li>\n<li style=\"color: #000000;line-height: 30px;font-size: 16px\">Le lien entre la composition des matrices alimentaires et la capacit\u00e9 du pathog\u00e8ne \u00e0 initier un processus infectieux<\/li>\n<li style=\"color: #000000;line-height: 30px;font-size: 16px\">Le d\u00e9veloppement d\u2019un outil d\u2019\u00e9valuation de la virulence innovant en remplacement aux mod\u00e8les animaux pour cribler des collections de souches pour lier biodiversit\u00e9 et pouvoir infectieux<\/li>\n<li style=\"color: #000000;line-height: 30px;font-size: 16px\">La mise en \u0153uvre d\u2019un dispositif commercial pour \u00e9valuer la capacit\u00e9 \u00e0 former des biofilms dans des conditions technologiques<\/li>\n<li style=\"color: #000000;line-height: 30px;font-size: 16px\">La lumi\u00e8re comme outil de d\u00e9sinfection pour le secteur agroalimentaire<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p class=\"titre2\" style=\"text-align: center;font-family: arial;color: #483d8b;font-size: 18px\"><strong style=\"color: #483d8b\">ORGANISATION DES ACTIVIT\u00c9S DE RECHERCHE<br \/>\n<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-family: calibri;color: #000000;padding-left: 60px;padding-right: 60px;font-size: 16px;text-align: justify\">Les activit\u00e9s de recherche de List_MAPS sont organis\u00e9es en 4 ensembles de t\u00e2ches combinant les approches globales (transcriptome et prot\u00e9ome), les approches classiques de biologie mol\u00e9culaire et les caract\u00e9risations physiologiques dans les quatre environnements contr\u00f4l\u00e9s:<\/p>\n<p class=\"titre2\" style=\"font-family: calibri;font-size: 16px;text-align: justify;color: #483d8b;padding-left: 90px;padding-right: 90px\"><strong style=\"color: #483d8b\">WP1: Data collection and integration in the specific environments<\/strong><\/p>\n<p style=\"font-family: calibri;color: #000000;padding-left: 90px;padding-right: 90px;font-size: 16px;text-align: justify\"><strong><em style=\"color: #000000\">Objectifs:<\/em>\u00a0<\/strong>Extraction des ARN et des prot\u00e9ines dans les divers environnements (t\u00e2che 1)\u00a0;\u00a0 \u00a0construction d\u2019une base de donn\u00e9e incluant l\u2019identification des \u00a0TSS, les analyses RNA-seq et MACE (t\u00e2che 2)\u00a0; et l\u2019int\u00e9gration des donn\u00e9es de transcriptomique et de prot\u00e9omique (t\u00e2che 3).<\/p>\n<p style=\"font-family: calibri;color: #000000;padding-left: 90px;padding-right: 90px;font-size: 16px;text-align: justify\"><strong><em style=\"color: #000000\">Partenaire responsable:<\/em><\/strong> GenXPro<\/p>\n<p class=\"titre2\" style=\"font-family: calibri;font-size: 16px;text-align: justify;color: #483d8b;padding-left: 90px;padding-right: 90px\"><strong style=\"color: #483d8b\">WP2: Linking environmental cues and expression of virulence<\/strong><\/p>\n<p style=\"font-family: calibri;color: #000000;padding-left: 90px;padding-right: 90px;font-size: 16px;text-align: justify\"><strong><em style=\"color: #000000\">Objectifs:<\/em><\/strong> \u00c9valuer l\u2019effet des constituants de la matrice alimentaire et de la pr\u00e9sence de chitine sur le niveau de virulence (t\u00e2che 1), exploitation des donn\u00e9es de transcriptome pour l\u2019analyse de l\u2019expression du virulon en fonction des conditions environnementales (t\u00e2che 2), \u00e9valuation de la virulence d\u2019une collection de mutants (t\u00e2che 3).<\/p>\n<p style=\"font-family: calibri;color: #000000;padding-left: 90px;padding-right: 90px;font-size: 16px;text-align: justify\"><strong><em style=\"color: #000000\">Partenaire responsable:<\/em> <\/strong>University College Cork<\/p>\n<p class=\"titre2\" style=\"font-family: calibri;font-size: 16px;text-align: justify;color: #483d8b;padding-left: 90px;padding-right: 90px\"><strong style=\"color: #483d8b\">WP3: Tools for evaluation of intra-specific phenotypic diversity<\/strong><\/p>\n<p style=\"font-family: calibri;color: #000000;padding-left: 90px;padding-right: 90px;font-size: 16px;text-align: justify\"><strong><em style=\"color: #000000\">Objectifs:<\/em>\u00a0<\/strong>D\u00e9veloppement et validation d\u2019un test innovant d\u2019\u00e9valuation de la virulence <em>in silico<\/em> en remplacement des mod\u00e8les animaux (t\u00e2che 1), d\u00e9veloppement d\u2019un kit d\u2019\u00e9valuation de la formation de biofilm (t\u00e2che 2), analyse de la diversit\u00e9 d\u2019une collection de souches avec ces outils (t\u00e2che 3).<\/p>\n<p style=\"font-family: calibri;color: #000000;padding-left: 90px;padding-right: 90px;font-size: 16px;text-align: justify\"><strong><em style=\"color: #000000\">Partenaire responsable:<\/em><\/strong> BioFilm Control<\/p>\n<p class=\"titre2\" style=\"font-family: calibri;font-size: 16px;text-align: justify;color: #483d8b;padding-left: 90px;padding-right: 90px\"><strong style=\"color: #483d8b\">WP4: Systems biology approach<\/strong><\/p>\n<p style=\"font-family: calibri;color: #000000;padding-left: 90px;padding-right: 90px;font-size: 16px;text-align: justify\"><strong><em style=\"color: #000000\">Objectifs:<\/em><\/strong> Mod\u00e9lisation des r\u00e9seaux de r\u00e9gulation (t\u00e2che 1), identification de g\u00e8nes cibles et approche de g\u00e9n\u00e9tique inverse (t\u00e2che 2), optimisation du mod\u00e8le gr\u00e2ce \u00e0 la confrontation des r\u00e9sultats exp\u00e9rimentaux et des hypoth\u00e8ses tir\u00e9es du mod\u00e8le th\u00e9orique (t\u00e2che 3).<\/p>\n<p style=\"font-family: calibri;color: #000000;padding-left: 90px;padding-right: 90px;font-size: 16px;text-align: justify\"><strong><em style=\"color: #000000\">Partenaire responsable:<\/em> <\/strong>INRA<\/p>\n<p>&nbsp;<\/p>\n<p class=\"titre2\" style=\"text-align: center;font-family: arial;color: #483d8b;font-size: 18px\"><strong style=\"color: #483d8b\">PROJETS DE RECHERCHE INDIVIDUELS<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-family: calibri;color: #000000;padding-left: 60px;padding-right: 60px;font-size: 16px;text-align: justify\">Le projet scientifique global du r\u00e9seau n\u00e9cessite la contribution de chacun des projets de recherche individuel. Ces projets individuels sont au c\u0153ur de la formation par la recherche des jeunes chercheurs.<\/p>\n<p>&nbsp;<\/p>\n<table style=\"height: 411px;border-color: #ffffff;background-color: #ffffff\" width=\"852\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td style=\"font-family: calibri;color: #ffffff;background-color: #483d8b\"><strong style=\"color: #ffffff\">Organisation<\/strong><\/td>\n<td style=\"font-family: calibri;color: #ffffff;background-color: #483d8b\"><strong style=\"color: #ffffff\">Titre du sujet individuel<br \/>\n<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\">Universit\u00e9 de Bourgogne (ESR 1)<\/td>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\"><a style=\"text-decoration: none;color: #483d8b\" href=\"http:\/\/blog.ube.fr\/list-maps\/early-stage-researchers\/angela-rocio-ortiz-camargo\/\"><strong style=\"color: #483d8b\">Investigation of the adaptative strategies of <em style=\"color: #483d8b\">L. monocytogenes<\/em> in soil\/plants mesocosms<\/strong><\/a><\/td>\n<\/tr>\n<tr>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\">Universit\u00e9 de Cork (ESR 2)<\/td>\n<td style=\"font-family: calibri;background-color: #ffffff\"><a style=\"text-decoration: none;color: #483d8b\" href=\"http:\/\/blog.ube.fr\/list-maps\/early-stage-researchers\/vanessa-las-heras\/\"><strong style=\"color: #483d8b\">Stress pre-adaptation and virulence potential of <em style=\"color: #483d8b\">L. monocytogenes<\/em> in the food matrix<\/strong><\/a><\/td>\n<\/tr>\n<tr>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\">Universit\u00e9 de Copenhague (ESR 3)<\/td>\n<td style=\"font-family: calibri;background-color: #ffffff\"><a style=\"text-decoration: none;color: #483d8b\" href=\"http:\/\/blog.ube.fr\/list-maps\/early-stage-researchers\/miguel-villoria-recio\/\"><strong style=\"color: #483d8b\">Regulation of the virulon of <em style=\"color: #483d8b\">L. monocytogenes<\/em> by carbohydrates<\/strong><\/a><\/td>\n<\/tr>\n<tr>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\">Universit\u00e9 Nationale d&#8217;Irlande, Galway (ESR 4)<\/td>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\"><a style=\"text-decoration: none;color: #483d8b\" href=\"http:\/\/blog.ube.fr\/list-maps\/early-stage-researchers\/amber-dorey\/\"><strong style=\"color: #483d8b\">Role of \u03c3B regulon of <em style=\"color: #483d8b\">L. monotogenes<\/em> in environmental stress resistance<\/strong><\/a><\/td>\n<\/tr>\n<tr>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\">INRA-UR454 (ESR 5)<\/td>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\"><a style=\"text-decoration: none;color: #483d8b\" href=\"http:\/\/blog.ube.fr\/list-maps\/early-stage-researchers\/tiago-santos\/\"><strong style=\"color: #483d8b\">Role of protein secretion in adaptation of <em style=\"color: #483d8b\">L. monocytogenes<\/em><\/strong><\/a><\/td>\n<\/tr>\n<tr>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\">Universit\u00e9 de Wageningue (ESR 6)<\/td>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\"><a style=\"text-decoration: none;color: #483d8b\" href=\"http:\/\/blog.ube.fr\/list-maps\/early-stage-researchers\/natalia-crespo-tapia\/\"><strong style=\"color: #483d8b\">Biodiversity and transmission of<em style=\"color: #483d8b\"> L. monocytogenes<\/em> in the food chain<\/strong><\/a><\/td>\n<\/tr>\n<tr>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\">Universit\u00e9 du Danemark du Sud (ESR 7)<\/td>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\"><a style=\"text-decoration: none;color: #483d8b\" href=\"http:\/\/blog.ube.fr\/list-maps\/early-stage-researchers\/patricia-dos-santos\/\"><strong style=\"color: #483d8b\">Role of non-coding sRNAs in the transmission of <em style=\"color: #483d8b\">L. monocytogenes<\/em> between environments<\/strong><\/a><\/td>\n<\/tr>\n<tr>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\">Universit\u00e9 de Bourgogne et Universit\u00e9 Nationale d&#8217;Irlande, Galway (ESR 8)<\/td>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\"><a style=\"text-decoration: none;color: #483d8b\" href=\"http:\/\/blog.ube.fr\/list-maps\/early-stage-researchers\/catarina-andreia-moreira-marinho\/\"><strong style=\"color: #483d8b\">Investigation of interconnections between AgrA and \u03c3B regulons<\/strong><\/a><\/td>\n<\/tr>\n<tr>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\">INRA-MaIAGE (ESR 9)<\/td>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\"><a style=\"text-decoration: none;color: #483d8b\" href=\"http:\/\/blog.ube.fr\/list-maps\/early-stage-researchers\/islam-ibrahim-sultan\/\"><strong style=\"color: #483d8b\">Transcription regulatory network construction<\/strong><\/a><\/td>\n<\/tr>\n<tr>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\">GenXPro (ESR 10)<\/td>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\"><a style=\"text-decoration: none;color: #483d8b\" href=\"http:\/\/blog.ube.fr\/list-maps\/early-stage-researchers\/ignasi-ferrer-lluis\/\"><strong style=\"color: #483d8b\">Development of bioinformatics tools for the analysis of MACE data<\/strong><\/a><\/td>\n<\/tr>\n<tr>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\">BioFilm Control et GenXPro (ESR 11)<\/td>\n<td style=\"font-family: calibri;color: #000000;background-color: #ffffff\"><a style=\"text-decoration: none;color: #483d8b\" href=\"http:\/\/blog.ube.fr\/list-maps\/early-stage-researchers\/bohyung-lee\/\"><strong style=\"color: #483d8b\">Development of innovative tools for rapid phenotypic characterisation of intraspecific diversity<\/strong><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p class=\"titre2\" style=\"font-family: calibri;color: #000000;font-size: 12px;text-align: center\"><a href=\"http:\/\/blog.ube.fr\/list-maps\/wp-content\/uploads\/sites\/34\/2015\/10\/eulogo.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-557 \" src=\"http:\/\/blog.ube.fr\/list-maps\/wp-content\/uploads\/sites\/34\/2015\/10\/eulogo.jpg\" alt=\"eulogo\" width=\"79\" height=\"46\" srcset=\"https:\/\/blog.ube.fr\/list-maps-fr\/wp-content\/uploads\/sites\/56\/2015\/10\/eulogo.jpg 600w, https:\/\/blog.ube.fr\/list-maps-fr\/wp-content\/uploads\/sites\/56\/2015\/10\/eulogo-300x175.jpg 300w\" sizes=\"auto, (max-width: 79px) 100vw, 79px\" \/><\/a>Ce projet est financ\u00e9 par les actions Marie-Sklodowska Curie du programme de recherche et d\u2019innovation de l\u2019Union europ\u00e9enne Horizon 2020 selon l\u2019accord de subvention n\u00b0641984<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00a0LE PROGRAMME SCIENTIFIQUE DE LIST_MAPS &nbsp; Les m\u00e9canismes permettant \u00e0 Listeria monocytogenes de transiter et de persister dans des habitats tr\u00e8s vari\u00e9s restent encore mal connus. Il est cependant clair que la capacit\u00e9 d\u2019int\u00e9grer des signaux environnementaux et de d\u00e9velopper une r\u00e9ponse appropri\u00e9e aux conditions de son environnement participe au risque sanitaire associ\u00e9 \u00e0 la&hellip;<\/p>\n<p class=\"more-link-p\"><a class=\"btn btn-primary\" href=\"https:\/\/blog.ube.fr\/list-maps-fr\/le-projet\/recherche\/\">Voir plus &rarr;<\/a><\/p>\n","protected":false},"author":99,"featured_media":0,"parent":2,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-28","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blog.ube.fr\/list-maps-fr\/wp-json\/wp\/v2\/pages\/28","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.ube.fr\/list-maps-fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blog.ube.fr\/list-maps-fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ube.fr\/list-maps-fr\/wp-json\/wp\/v2\/users\/99"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ube.fr\/list-maps-fr\/wp-json\/wp\/v2\/comments?post=28"}],"version-history":[{"count":53,"href":"https:\/\/blog.ube.fr\/list-maps-fr\/wp-json\/wp\/v2\/pages\/28\/revisions"}],"predecessor-version":[{"id":1547,"href":"https:\/\/blog.ube.fr\/list-maps-fr\/wp-json\/wp\/v2\/pages\/28\/revisions\/1547"}],"up":[{"embeddable":true,"href":"https:\/\/blog.ube.fr\/list-maps-fr\/wp-json\/wp\/v2\/pages\/2"}],"wp:attachment":[{"href":"https:\/\/blog.ube.fr\/list-maps-fr\/wp-json\/wp\/v2\/media?parent=28"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}