Whilst WG2 will focus on changes on the organism as a whole and WG3 will consider the impact on
\nthe microbiome, WG4 will investigate changes at the cellular level. Such cellular events are often
\nindicative of changes to the whole organism, and in may ways bridge the gap – in vivo and also in
\nour understanding – between the individual compound on one side and its complex interactions with
\nthe organism on the other. A diverse array of cell-based analytical techniques will be assembled to
\ninvestigate how individual substances, either alone or in combination, act on cells and interact with
\nrelevant cellular constituents, including the genome and epigenome. The topics of WG4 bring in
\nanother barrage of bioanalytical techniques, which include emerging proteomic and (nutri)genomic
\nmethods, the latest molecular cell and fluorescent based staining and imaging techniques as well as
\nLive Cell Imaging and chemogenetic screening to obtain a more global assessment of events. This
\nWG will also investigate redox related nutri-epigenetic events.<\/p>\n
<\/p>\n